In nuclear industry, cyclone separator is often used for gas-solid separation in circumstances such as transporting, processing and dust-controlling of uranium compound powders. In this study, the influence of temperature on the separation performance and flow field of a cyclone separator was simulated by using the commercial software Barracuda based on the MP-PIC model. The aim of this study is to test the feasibility of MP-PIC model in predicting the performance of the cyclone separator. The results show that the MP-PIC model can simulate the influence trends of inlet gas velocity and temperature on the performance indicators of the cyclone separator. The predicted performance and flow field parameter variation laws are generally in good agreement with the experimental results. However, the predicted vortex strength is quantitatively weaker than experimental results, and this is mainly reflected in the fact that the pressure drop and gas velocity obtained from the simulation are both to some extent lower than the experimental values. This is related to the large eddy turbulence model and the relatively low grid resolution used in the simulation.