The effects of Cu/CeO2 catalysts with Cu loading of 10%, 20% and 30% on the performance of CO2 hydrogenation to methanol were studied. Characterization methods such as XRD, BET and CO2-TPD were adopted to preliminarily investigate the mechanism of the influence of Cu loading on the hydrogenation performance of the catalyst. The results show that: Within the scope of this study, the catalyst with Cu loading of 20% had the best activity. When the reaction temperature was 240 ℃, the reaction pressure was 3 MPa, the mass space velocity was 12000 mL/(gcat·h), and H2/CO2=3:1, the selectivity and spatiotemporal yield of CH3OH were 85.2% and 13.8 g/(kgcat·h), respectively. Among the three catalysts, the catalyst with Cu loading of 20% showed the smallest lattice parameters and grain size of CeO2, the largest specific surface area, and the largest number of basic active sites. This indicates that an appropriate Cu loading can enhance the dispersion of Cu species on the surface of the CeO2 carrier, increase the contact area between the reaction raw materials and the catalyst, and improve the adsorption capacity of the catalyst for CO2 molecules. Thus, the catalytic performance of the Cu/CeO2 catalyst in the reaction of CO2 hydrogenation to methanol is improved.