Pressure solution is a dominant deformation mechanism in aseismic creep, which controls the crack healing kinetics around active faults. Experimental study of pressure solution-induced creep during post-seismic stress relaxation can greatly contribute to the understanding of deformation processes during earthquake cycles in active fault zones. This article presents an experimental study simulating the physical mechanisms during post-seismic stress relaxation in a pressure solution-dominated fault zone, explored via shear deformation of Carrara marble under the temperature of 200–500 °C, a confining pressure of 800 MPa and a strain rate of 1 × 10?7 s?1 with water content ranging from 0.17% to 0.82%. Herein, the microstructure and deformation mechanisms of the deformed samples were studied using optical microscopy and scanning electron microscopy. The experimental results show a transition from transient creep to steady-state creep when the temperature rises from 200 to 500 °C. Samples deformed at 200–350 °C indicate deformation mechanisms related to transient creep, including pressure solution, mechanical twinning, fractures and cataclastic. Alternatively, samples deformed at 400–500 °C represent steady-state creep during the interseismic period, which is characterised by dislocation glide and dynamic recrystallization accompanied by pressure solution. It is concluded that pressure solution is a very important mechanism that operates during post-seismic stress relaxation and controls the aseismic sliding of active faults.