Based on geological and geophysical data, the Paleogene syndepositional fault and its control on sequence architecture of Lingshui sag were studied by analyzing the combination features and faulting-activity rate of the fault. The results show that three kinds of frameworks, i.e., asymmetric graben, symmetric graben and half-graben, were developed individually in the east, middle, and west of Lingshui sag. Three kinds of structural paleogeomorphologies, i.e., up-dip foot slope break belt, down-dip foot slope break belt and gentle slope-break belt, were developed in response to the changes of faulting-activity, which influenced the sequence-infill patterns. Different sequence-infill patterns distributing within tectono-stratigraphic frameworks have characteristic sequence architectures, which will favorably contribute to exploration of potential reservoirs and subtle oil pools in deepwater area.